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Click to chatradiopaque intraluminal stents comprising cobalt based alloys containing one or more platinum group metals refractory metals or combinations thereofpatent
Click to chat6032 Background In the randomized phase III Study CA209141 Nivolumab N demonstrated significant overall survival OS benefit with favorable safety profile for platinum refractory R/M SCCHN and is now approved for these patients pts The objectives of the study are to provide additional insight into the frequency of high grade AEs related to N and the efficacy of N in real life Methods
Click to chat11 03 2010 Platinum refractory or resistant ovarian cancer is defined by the Gynecologic Oncology Group GOG as persistent disease or progression within 6 months following platinum based therapy and is associated with a low response rate to further treatment responses of short duration and a median survival of less than 1 year.
Click to chat08 07 2020 Platinum refractory advanced EOC accounts for only 20 of patients with advanced EOC as such there have been few trials focused exclusively on this patient population Treatment is typically extrapolated from trials of patients with recurrent platinum resistant disease although some trials also included patients with platinum refractory
Click to chatThe platinum group metals can be described as refractory metals because of their high melting points This group comprises platinum osmium iridium ruthenium rhodium and palladium i e metals which have properties similar to those of platinum The metals in this group
Click to chat30 03 2012 The term platinum resistant developed over the last two decades by Markman and others is used to describe patients who initially respond to platinum based chemotherapy and then relapse within six months of treatment While platinum refractory seems intuitively obvious it has been suggested that platinum resistance is somewhat more
Click to chat19 11 2018 JAVELIN Ovarian 200 enrolled a high proportion of patients with aggressive refractory disease that had no response to prior platinum based chemotherapy a population known to have disease that is challenging to treat as such this group of patients is typically not included in Phase III ovarian cancer trials said Chris Boshoff M.D Ph.D Senior Vice President and Head of Immuno
Click to chatObjective The objective of this article is to describe real world treatment patterns and outcomes in patients with platinum refractory/resistant epithelial ovarian fallopian tube or primary peritoneal cancer PRROC in the United States United Kingdom and Canada Methods/Materials Physicians retrospectively reviewed medical records of women aged 18 years or older who were diagnosed with
Click to chatAdding cetuximab to platinum based chemotherapy with fluorouracil platinum–fluorouracil significantly prolonged the median overall survival from 7.4 months in the chemotherapy alone group to
Click to chatTianjin Monocon Refractories Co Ltd was established in TEDA in 2002 by Monocon International Refractories Ltd By the end of 2005 India s leading refractory company IFGL Refractories Ltd acquired the entire Monocon Group including its subsidiaries in China Taiwan and USA.
Click to chat17 04 2019 WGA in Platinum refractory HNSCC Underwent Nivolumab The safety and scientific validity of this study is the responsibility of the study sponsor and investigators Listing a study does not mean it has been evaluated by the U.S Federal Government.
Click to chat06 07 2020 NICE s rejection of pembrolizumab for platinum refractory urothelial carcinoma is there a Median OS was 10.3 months with pembrolizumab versus 7.4 months in the chemotherapy group
Click to chat31 01 2018 The word refractory in general use means stubborn or intractable and in medicine it is specifically applied to disease that does not respond to treatment Refractory cancer refers to cancer that may be resistant at the beginning of treatment or becomes resistant during treatment We would consider disease refractory
Click to chatTreatments for Platinum Resistant or Refractory Recurrence The tables below click to open list the drugs most commonly used for treating cancer has progressed on treatment ie refractory or has come back less than 6 months after the last platinum treatment ie resistant Groups of drugs are used in combination These drugs are listed in the National Comprehensive Cancer Network
Click to chat9 hours ago Platinum Group Metals Ltd provides the following Waterberg Project update Geotechnical Drilling A geotechnical drilling campaign at the Waterberg Project which commenced in 2021 is now in
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Click to chatTaken together these results indicate that afatinib may be effective in extending survival in patients with platinum refractory urothelial carcinoma with HER2 or ERBB3 alterations and support further study of afatinib in larger clinical trials focused on this
Click to chat18 07 2011 Purchase Extractive Metallurgy of Nickel Cobalt and Platinum Group Metals1st Edition Print Book E Book ISBN
Click to chatThe forming of an adherent platinum coating on the surface of hard highly dense refractories by plasma flame spraying thereon an intermediate layer of a refractory oxide selected from the group comprised of zirconia zircon alumina cordierite mullite or zirconia alumina silica having a particle size between 140 and 200 mesh and further plasma sraying thereon a substantially 20 100 micron
Click to chatPlatinum group metals base refractory superalloys for ultra high temperature use Y Yamabe Mitarai Y Ro T Maruko T Yokokawa and H Harada Structural Intermetallics 1997 1997 p 805 Ir base refractory superalloys for ultra high temperature use
Click to chatSome CAI s containmicron sized metal nuggets in which the normally incompatible refractory Mo Re W and platinum group Pt Os Ir Ru metals are alloyed together in approximately cosmic
Click to chatAltretamine hexamethylmelamine in platinum resistant and platinum refractory ovarian cancer a Gynecologic Oncology Group phase II trial Markman M 1 Blessing JA Moore D Ball H Lentz SS Author information 1 Department of Hematology/Medical Oncology Cleveland Clinic Cancer Center Cleveland Clinic Foundation Ohio 44195 USA.
Click to chat26 03 2018 Platinum refractory patients typically have even lower response rates and NCCN treatment guidelines recommend this group s average
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Click to chat01 07 2007 In this study a single agent docetaxel 60 mg/m 2 regimen for the treatment of platinum refractory SCCHN appeared to have good clinical efficacy and an acceptable safety profile The prognosis of platinum refractory SCCHN patients was poor and the median survival in this population with best supportive care was only 56 days .
Click to chat10 12 2018 Terence Bell Updated December 10 2018 The term refractory metal is used to describe a group of metal elements that have exceptionally high melting points and are resistant to wear corrosion and deformation Industrial uses of the term refractory metal most often refer to five commonly used elements Molybdenum Mo
Click to chatGynecologic Oncology Group Markman M Blessing J et al Phase II trial of weekly paclitaxel 80 mg/m2 in platinum and paclitaxel resistant ovarian and primary peritoneal cancers a Gynecologic Oncology Group study Gynecol Oncol 2006 101 436.
Click to chatThe forming of an adherent platinum coating on the surface of hard highly dense refractories by plasma flame spraying thereon an intermediate layer of a refractory oxide selected from the group comprised of zirconia zircon alumina cordierite mullite or zirconia alumina silica having a particle size between 140 and 200 mesh and further plasma sraying thereon a substantially 20 100 micron
Click to chat09 10 2021 A stage IV vs stage I III at rrHL B refractory disease vs TTR > 3 months C PFS at rrHL according to risk group at 1st diagnosis PFS progression free survival rrHL relapsed or refractory
Click to chatA refractory metallic oxide ceramic part suitable for use in the processing of molten glass said part comprising at least one surface area having a surface drilled to develop an array of slots or closed end holes and in which at least a portion of such treated surface carries a platinum group metal or platinum group metal alloy coating pegged thereto by the mechanical interaction between
Click to chat01 02 2011 11 years ago Here s my understanding Platinum refractory cancer grew while on platinum therapy Platinum resistant recurrance within 6 months of platinum treatment However I think they are more often than not used to mean the same thing.
Click to chat11 04 2011 So in reading this I realize that he is considering me a platinum refractory patient recurring in 6 months I recurred after 8 months initially but this last taxol/carbo didn t put me into remission So I assume that what category you are in is determined by your last experience with platinum.
Click to chat01 08 2019 Sources of Platinum Group Metals Platinum gets its name from platina meaning little silver because the Spaniards considered it an unwanted impurity in silver mining operations in Colombia.For the most part PGMs are found together in ores Ultramafic and mafic igneous rocks contain high levels of platinum group metals the granites contain a low percentage of the metals.
Click to chat09 08 2018 In The Lancet Oncology Radoslav Chekerov and colleagues1 report the results of a randomised phase 2 trial of the efficacy and safety of adding sorafenib an oral tyrosine kinase inhibitor of the VEGF receptor and Ras Raf MEK and ERK signalling pathways to topotecan during chemotherapy and in maintenance in recurrent platinum resistant or platinum refractory ovarian cancer.1 The
Click to chatThe occurrence of many phases in platinum group metal alloys or even more generally in transition metal alloys correlates amazingly simply with electron/atom ratio or as we have preferred to call it group number One example is the HCP structure that occurs in alloys in the average group number range 7
Click to chatFingerprint Dive into the research topics of Relevance of platinum sensitivity status in relapsed/refractory extensive stage small cell lung cancer in the modern era A patient level analysis of Southwest Oncology Group trials .
Click to chat01 01 2015 Some studies opted to solely focus on the platinum sensitive group excluding those with refractory disease 3 4 In Southwest Oncology Group SWOG trials in previously treated SCLC since 2000 have mandated independent accrual to platinum sensitive and platinum refractory strata to account for the possibility of differential outcomes to investigational therapies between these groups.
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Click to chatTreatments for Platinum Resistant or Refractory Recurrence The tables below click to open list the drugs most commonly used for treating cancer has progressed on treatment ie refractory or has come back less than 6 months after the last platinum
Click to chatThe forming of an adherent platinum coating on the surface of hard highly dense refractories by plasma flame spraying thereon an intermediate layer of a refractory oxide selected from the group comprised of zirconia zircon alumina cordierite mullite or zirconia alumina silica having a particle size between 140 and 200 mesh and further plasma sraying thereon a substantially 20 100 micron
Click to chatDOI 10.1007/s12032 017 0960 z Corpus ID A brief review of the management of platinum resistant–platinum refractory ovarian cancer article Oronsky2017ABR title= A brief review of the management of platinum resistant–platinum refractory ovarian cancer author= B Oronsky and Carolyn M Ray and A Spira and J Trepel and C Carter and H Cottrill journal= Medical Oncology
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